What is the primary route of administration for aminoglycosides?

Aminoglycosides are primarily administered intravenously or intramuscularly due to their poor absorption and bioavailability when taken orally. These antibiotics are often used to treat serious infections caused by Gram-negative bacteria and require optimal serum levels to be effective. Administering aminoglycosides via the intravenous or intramuscular route ensures that therapeutic levels are achieved quickly in the bloodstream, which is crucial for their effectiveness against severe infections. This method also allows for closer monitoring of drug levels and potential nephrotoxicity or ototoxicity, as aminoglycosides can have significant side effects and require careful dosing adjustments based on renal function. Other routes of administration, such as topically, orally, or sublingually, are not suitable for aminoglycosides, limiting their effectiveness in treating systemic infections.