What is the best indicator of aminoglycoside toxicity?

Aminoglycosides are a class of antibiotics known for their effectiveness against certain bacterial infections, but they also have a potential for toxicity. Ototoxicity, which refers to damage to the inner ear that can affect balance and hearing, is a particularly concerning side effect of aminoglycosides. This toxicity can occur due to the drug's accumulation in the inner ear, leading to irreversible hearing loss and balance issues.

Monitoring for signs of ototoxicity is crucial as this side effect can develop with prolonged use or high doses. Symptoms may include tinnitus (ringing in the ears), vertigo, or hearing loss, and the onset can sometimes be abrupt. Identifying these symptoms early allows for prompt intervention, potentially avoiding permanent damage.

While nephrotoxicity is also a significant concern with aminoglycosides, the best indicator of toxicity, specifically concerning the inner ear's function and related symptoms, points toward ototoxicity. Other effects, such as gastrointestinal distress or dermatologic reactions, while they may occur, are generally not regarded as the primary indicators of aminoglycoside toxicity.