What is the antidote for Heparin overdose?

Protamine sulfate is the specific antidote for heparin overdose. Heparin, an anticoagulant, prevents blood clots by inhibiting certain factors in the coagulation pathway. In cases of overdose, Protamine sulfate works by neutralizing the effects of heparin, thereby reversing its anticoagulant properties. This is particularly important in clinical situations where excessive bleeding may occur due to heparin's action, such as during surgical procedures or in patients with compromised hemostasis.

Using Protamine sulfate effectively restores the normal clotting function and is critical for ensuring patient safety when anticoagulation therapy goes awry. It should be administered carefully, considering the weight of the patient and the amount of heparin they have received, in order to achieve the desired reversal of anticoagulation without causing adverse reactions.