What is a classic physical sign of Cushing's Syndrome?

The classic physical sign of Cushing's Syndrome is characterized by the presence of a "moon face." This refers to the distinctive rounding of the face that occurs as a result of excess cortisol in the body. Cushing's Syndrome, often caused by conditions such as a pituitary tumor or prolonged use of corticosteroids, leads to a redistribution of body fat and fluid retention. The moon facies are often accompanied by other signs such as a buffalo hump, central obesity, and skin changes, which are all manifestations of this hormonal imbalance.

In contrast to the other options, a loss of body hair typically is not associated with Cushing's Syndrome and may be seen in conditions like Androgen Insensitivity Syndrome. Hypotension is not a hallmark of Cushing's; instead, individuals often experience hypertension due to sodium retention. Increased height is not associated with Cushing's Syndrome, as the condition usually does not impact growth in adults and is more related to hormonal imbalances that affect other metabolic functions. Thus, the moon face is a key clinical feature that aligns with the physiological changes seen in Cushing's Syndrome.