What happens physiologically during withdrawal from a downer?

During withdrawal from a downer, such as a sedative or depressant, the physiological response of the body is characterized by increased activity in the central nervous system. This change is due to the body's adaptation to the depressant effects of the substance; when the substance is no longer present, the body can experience heightened levels of anxiety, agitation, and hyperactivity.

As the depressant effects wear off, there is a rebound effect where various bodily functions that were previously slowed down become more pronounced. Heart rate may increase, blood pressure can rise, and the individual may exhibit symptoms such as tremors, insomnia, and increased sensory perception. This overactivity is a direct response as the body works to regain homeostasis after the removal of the substance that was previously exerting a calming effect.

This physiological state contrasts with the state maintained during the use of downers, where everything tends to slow down due to the substance's depressant qualities. Following withdrawal, the system "overcorrects" due to its previous adaptations, leading to the experience of heightened physiological activity.