What are the two long-term problems associated with diabetes?

The correct choice identifies peripheral neuropathy and poor tissue perfusion as two long-term complications associated with diabetes. Diabetes can lead to nerve damage, particularly in the extremities, which is known as peripheral neuropathy. This condition manifests as pain, tingling, or loss of sensation in the feet and hands.

Additionally, diabetes can impair blood circulation due to damage to the blood vessels, resulting in poor tissue perfusion. This insufficiency can lead to serious complications such as foot ulcers, infections, and in severe cases, may necessitate amputation. Understanding these risks is essential for diabetes management and prevention of complications.

Other options represent important health concerns related to diabetes but do not directly align with the long-term complications most commonly recognized. For instance, while diabetic retinopathy is a significant complication, ketoacidosis is an acute condition that primarily occurs in type 1 diabetes rather than a long-term complication. Hypertension and hyperlipidemia are often comorbid conditions associated with diabetes but are not exclusive complications resulting directly from the disease. Lastly, while heart disease is a serious risk for those with diabetes, labeling it broadly as neuropathy and heart disease does not specifically address the prevalent long-term issues of neuropathy and perfusion problems.