How do Calcium Channel Blockers primarily affect blood vessels?

Calcium channel blockers primarily affect blood vessels by causing them to dilate. They work by inhibiting the influx of calcium ions into smooth muscle cells within the arterial walls. Calcium is essential for muscle contraction, so by blocking these channels, the smooth muscle relaxes. This relaxation leads to vasodilation, which reduces vascular resistance and ultimately lowers blood pressure. As a result, blood flow increases to various tissues because the dilated blood vessels can accommodate more blood, improving circulation. This mechanism is crucial for the management of conditions like hypertension and certain types of angina.